SAB4200551
Anti-MST1R antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
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Synonym(s):
Anti-CD136, Anti-CDw136, Anti-MST1R variant RON30, Anti-MST1R variant RON62, Anti-Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), Anti-PTK8, Anti-PTK8 protein tyrosine kinase 8, Anti-RON, Anti-RON variant E2E3, Anti-c-met-related tyrosine kinase, Anti-macrophage-stimulating protein receptor, Anti-p185-Ron
UNSPSC Code:
12352203
NACRES:
NA.44
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~170 kDa
species reactivity
rat, human
concentration
~1.0 mg/mL
technique(s)
western blot: 2.5-5.0 μg/mL using whole extracts of human HT-29 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MST1R(4486)
rat ... Mst1r(300999)
General description
Macrophage-stimulating protein receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. It is a heterodimer of disulfide-linked α- and β-subunits, generated by proteolytic cleavage of a single-chain precursor. MST1R is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung. It belongs to the MET receptor tyrosine kinase family. MST1R is located on the human chromosome at 3p21.31.
Specificity
Anti-MST1R recognizes human MST1R.
Immunogen
synthetic peptide corresponding to an internal region of human MST1R, conjugated to KLH. The corresponding sequence is identical in rat and differs by 2 amino acids in mouse.
Application
Anti-MST1R antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Macrophage-stimulating protein receptor (MST1R) takes part in tumorigenesis. MST1R along with MSP is involved in host defense. Mutation of MST1R is associated with carcinoma of the breast, bladder, lung, colon, prostate, ovary and pancreas. Increased levels of MST1R is observed in aggressive tumors with poor patient survival.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Selection and evolution in the genomic landscape of copy number alterations in ductal carcinoma in situ (DCIS) and its progression to invasive carcinoma of ductal/no special type: a meta-analysis
Rane S U, et al.
Breast Cancer Research and Treatment, 153(1), 101-121 (2015)
An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells
Liu H S, et al.
Carcinogenesis, 31(8), 1456-1464 (2010)
Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance
Han W, et al.
Chinese Medical Journal (English Edition), 125(6), 1110-1114 (2012)
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.
Daniel V T Catenacci et al.
Cancer biology & therapy, 12(1), 9-46 (2011-05-06)
RON (MST1R) is one of two members of the MET receptor tyrosine kinase family, along with parent receptor MET. RON has a putative role in several cancers, but its expression and function is poorly characterized in gastroesophageal adenocarcinoma. A recognized
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