SAB4200528
Anti-HMGCR antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
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All Photos(2)
Synonym(s):
Anti-3-hydroxy-3-methylglutaryl-CoA reductase, LDLCQ3
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 100 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1.0-2.0 μg/mL using mevastatin-treated HepG2 cells.
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HMGCR(3156)
General description
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97 kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
Immunogen
synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and has 87% sequence identity in mouse HMGCR and 81% identity in rat HMGCR.
Application
Anti-HMGCR antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma. Polymorphism in HMGCR results in late-onset Alzheimer′s disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.
Chang XL, et al.
Oncotarget, 7(16), 22746?22751-22746?22751 (2016)
Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila.
Belgacem YH and Martin JR
PLoS ONE, 2(1), e187-e187 (2007)
Jittima Tomacha et al.
Frontiers in pharmacology, 12, 696961-696961 (2021-08-24)
An aberrant regulation of lipid metabolism is involved in the pathogenesis and progression of cancer. Up-regulation of lipid biosynthesis enzymes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN) and HMG-CoA reductase (HMGCR), has been reported in many cancers. Therefore, elucidating
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila
Belgacem YH and Martin JR
PLoS ONE, 2 (2007)
HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells.
Chushi L
Gene, 587, 42-47 (2016)
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