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SAB4200519

Sigma-Aldrich

Anti-GLUT1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

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Synonym(s):
Anti-SLC2A1, Anti-member 1, Anti-solute carrier family 2 (facilitated glucose transporter)
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~55-70 kDa

species reactivity

mouse, rat, human

concentration

~1.0 mg/mL

technique(s)

western blot: 0.5-1.0 μg/mL using rat spinal cord extracts (S1 fraction)

UniProt accession no.

P11166

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC2A1(6513)
mouse ... Slc2a1(20525)
rat ... Slc2a1(24778)

General description

Glucose transporter 1 (GLUT1, SLC2A1) belongs to the family of glucose transporters (GLUTs). It is localized to the membrane and is highly expressed in the brain and spinal cord, with a relative high density in the cerebellum. The vascular form of GLUT1 is mainly localized in endothelial cells of blood vessels.

Immunogen

peptide corresponding to a sequence at the C-terminus of human GLUT1, conjugated to KLH. The corresponding sequence is identical in rat and mouse GLUT1.

Application

Anti-GLUT1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

GLUT1 is the main glucose transporter in the blood-brain barrier (BBB), which regulates basal glucose levels. Increased expression of GLUT1 is associated with cell growth and in malignant transformation.

Physical form

solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Glucose transporters: expression, regulation and cancer
Medina RA and Owen GI
Biological Research, 35(1), 9-26 (2002)
Photobiomodulatory effects of superpulsed 904 nm laser therapy on bioenergetics status in burn wound healing
Yadav A, et al.
Journal of Photochemistry and Photobiology. B, Biology, 162, 77-85 (2016)
Differential localization of glucose transporter isoforms in non-polarized mammalian cells: distribution of GLUT1 but not GLUT3 to detergent-resistant membrane domains
Sakyo T and Kitagawa T
Biochimica et Biophysica Acta - Biomembranes, 1567, 165-175 (2002)
Aarón Guerrero et al.
Frontiers in cardiovascular medicine, 8, 644797-644797 (2021-06-29)
Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin
Immunohistochemical localization and quantification of glucose transporters in the mouse brain
Choeiri C, et al.
Neuroscience, 111(1), 19-34 (2002)

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