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SAB4200436

Sigma-Aldrich

Anti-COG7 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-CDG2E, Anti-Component of oligomeric golgi complex 7

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~86 kDa

species reactivity

human, mouse, rat

concentration

~1.0 mg/mL

technique(s)

western blot: 2.5-5.0 μg/mL using whole extracts of human HeLa, mouse NIH-3T3 or rat PC12 cells.

UniProt accession no.

P83436

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COG7(91949)
mouse ... Cog7(233824)
rat ... Cog7(293456)

General description

Conserved Oligomeric Golgi complex 7 (COG7) protein belongs to the COG complex. COG complex contains eight distinct subunits arranged in two heterotrimeric groups, COG2, 3, 4 and COG5, 6, 7 which are linked by a dimeric group formed by COG1 and COG8. COG complex is an evolutionarily conserved multi-subunit protein complex. The COG7 gene is mapped on the human chromosome at 16p12.2.

Specificity

Anti-COG7 (N-terminal) recognizes human, mouse and rat COG7.

Immunogen

peptide corresponding to the N-terminal region of human COG7, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat COG7.

Application

Anti-COG7 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Conserved Oligomeric Golgi complex (COG) plays a role in regulating membrane trafficking and maintenance of the eukaryotic Golgi glycosylation system. COG7 protein functions in retrograde vesicular trafficking. Mutations in the COG7 gene are associated with congenital disorder of glycosylation, type IIe.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
052M4780

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Eva Morava et al.
European journal of human genetics : EJHG, 15(6), 638-645 (2007-03-16)
We describe the clinical and biochemical characteristics in three patients from two different families diagnosed with Congenital Disorder of Glycosylation type IIe owing to a defect in Conserved Oligomeric Golgi complex (COG)7; one of the eight subunits of the COG.
Renate Zeevaert et al.
European journal of medical genetics, 52(5), 303-305 (2009-07-07)
We describe a patient homozygous for a novel mutation in COG7, coding for one of the subunits of the Conserved Oligomeric Golgi complex, involved in retrograde vesicular trafficking. His brother showed a similar clinical syndrome and glycosylation defect but no
G Charles Ostermeier et al.
Journal of andrology, 26(1), 70-74 (2004-12-22)
We recently described a complex population of spermatozoal coding RNAs that are delivered to the oocyte on fertilization. These are derived throughout spermatogenesis, representing a record of past events. Recently, evidence has been provided that micro-RNAs are present in testes
Rita Quental et al.
BMC evolutionary biology, 10, 212-212 (2010-07-17)
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by

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