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SAB4200326

Sigma-Aldrich

Anti-LRP1B (C-terminal region) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-LRP-DIT, Anti-LRPDIT, Anti-Low density lipoprotein receptor-related protein 1B

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~190 kDa (Rat)
antigen ~200 kDa (Human)

species reactivity

human, rat, mouse

concentration

~1.5 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B.
indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B.
western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction).

UniProt accession no.

Q9NZR2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRP1B(53353)
mouse ... Lrp1b(94217)
rat ... Lrp1b(311926)

General description

LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.

Application

Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells
Liu CX, et al.
The Journal of Biological Chemistry, 282(10), 7504-7511 (2007)
Joana Peixoto et al.
International journal of molecular sciences, 24(14) (2023-07-29)
LRP1B remains one of the most altered genes in cancer, although its relevance in cancer biology is still unclear. Recent advances in gene editing techniques, particularly CRISPR/Cas9 systems, offer new opportunities to evaluate the function of large genes, such as
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
Cam JA, et al.
The Journal of Biological Chemistry, 279(28), 29639-29646 (2004)
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu G
Nature Reviews. Neuroscience, 10(5), 333-333 (2009)
Can-Hui Cao et al.
International journal of biological sciences, 17(7), 1744-1756 (2021-05-18)
Human papillomavirus (HPV) infection and gene mutations were reputed as key factors in cervical carcinoma (CC) and head and neck squamous cell carcinoma (HNSCC). However, the associations of HPV status and gene mutations remain to be determined. This study aims

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