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SAB4200267

Sigma-Aldrich

Anti-O-GlcNAcase (OGA) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

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Synonym(s):
Anti-Beta-N-acetylhexosaminidase, Anti-Hexosaminidase C, Anti-MEA5, Anti-Meningioma expressed antigen 5 (hyaluronidase), Anti-N-acetyl-beta-D-glucosaminidase, Anti-N-acetyl-beta-glucosaminidase, Anti-NCOAT
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~130 kDa

species reactivity

human, mouse, canine

concentration

~1.5 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using A431 cells
western blot: 1.5-3.0 μg/mL using MDCK and mouse kidney extracts.

UniProt accession no.

O60502

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MGEA5(10724)
mouse ... Mgea5(76055)
rat ... Mgea5(154968)

Immunogen

synthetic peptide corresponding to a sequence located near the N-terminus of human O-GlcNAcase (OGA), conjugated to KLH. The corresponding sequence is identical in human OGA isoform B, and in rat and mouse OGA.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the immunogen sequence used to develop antibody SAB4200267, Anti-O-GlcNAcase (OGA) antibody produced in rabbit?

    The immunogen sequence used to develop antibody SAB4200267, Anti-O-GlcNAcase (OGA) antibody produced in rabbit, is: TYLYAPKDDYKHRMFWRE. 

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Fuxing Zhou et al.
Theranostics, 8(19), 5200-5212 (2018-12-18)
Cisplatin resistance significantly affects the survival rate of patients with ovarian cancer. However, the main mechanism underlying cisplatin resistance in ovarian cancer remains unclear. Methods: Immunohistochemistry was used to determine the expression of OGT, OGA and O-GlcNAc in chemoresistant and
Yuntian Shen et al.
Journal of the American Heart Association, 7(17), e009634-e009634 (2018-10-30)
Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal health, but is impaired after CA , we investigated
Kristin Halvorsen Hortemo et al.
Physiological reports, 3(2) (2015-02-26)
Myosin light chain 2 (MLC2) is a small protein in the myosin complex, regulating muscle contractile function by modulating Ca(2+) sensitivity of myofilaments. MLC2 can be modified by phosphorylation and O-GlcNAcylation, two reversible and dynamic posttranslational modifications. The slow isoform
Villo Muha et al.
The Journal of biological chemistry, 295(26), 8636-8646 (2020-02-26)
O-GlcNAcylation is an abundant post-translational modification in neurons. In mice, an increase in O-GlcNAcylation leads to defects in hippocampal synaptic plasticity and learning. O-GlcNAcylation is established by two opposing enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). To investigate the role
Sung-Kyun Park et al.
Cell reports, 20(5), 1088-1099 (2017-08-03)
Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear.
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