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SAB4200191

Sigma-Aldrich

Anti-Septin 9 antibody, Rat monoclonal

clone Clone 1A6C2, purified from hybridoma cell culture

Synonym(s):

Anti-MLL, Anti-MSF, Anti-MSF1, Anti-NAPB, Anti-PEANUT-LIKE 4, Anti-PNUTL4, Anti-SEPT9, Anti-SINT1, Anti-SeptD1, Monoclonal Anti-Septin 9 antibody produced in rat

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rat

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

Clone 1A6C2, monoclonal

form

buffered aqueous solution

mol wt

~72 kDa

species reactivity

human, rat, monkey, mouse

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: 2.5-5.0 μg/mL using L929, HeLa, 3T3 and COS-7 cell extracts

isotype

IgG2a

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SEPT9(10801)
mouse ... Sept9(53860)
rat ... Sept9(83788)

Related Categories

General description

Monoclonal Anti-Septin 9 (rat IgG2a isotype) is derived from the hybridoma 1A6C2 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a synthetic peptide of corresponding to the N-terminus of rat Septin 9, conjugated to KLH. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1). This gene is mapped to human chromosome 17q25.

Immunogen

synthetic peptide of corresponding to the N-terminus of rat Septin 9 conjugated to KLH

Application

Monoclonal Anti-Septin 9 has been used in:
  • immunoblotting
  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence

Biochem/physiol Actions

Septin 9 (SEPT9) has been implicated in tumorigenesis. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. In addition, SEPT9 is shown to be a DNA methylation-based biomarker, effectively discriminated colorectal cancer from normal specimens.

Physical form

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Eva P Karasmanis et al.
Current biology : CB, 29(13), 2174-2182 (2019-06-18)
Abscission is the terminal step of mitosis that physically separates two daughter cells [1, 2]. Abscission requires the endocytic sorting complex required for transport (ESCRT), a molecular machinery of multiple subcomplexes (ESCRT-I/II/III) that promotes membrane remodeling and scission [3-5]. Recruitment
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
Gulten T, et al.
Journal of Clinical Laboratory Analysis, 23(6), 368-371 (2009)
Taro Tachibana et al.
Hybridoma (2005), 29(2), 169-171 (2010-05-07)
The septin family of GTPase proteins has been shown to be important for cell division, cytoskeletal organization, and membrane-remodeling events. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1) and has been implicated in tumorigenesis. The
Polarity of neuronal membrane traffic requires sorting of kinesin motor cargo during entry into dendrites by a microtubule-associated septin
Karasmanis EP, et al.
Developmental Cell, 46(2), 204-218 (2018)
Mutations in SEPT9 cause hereditary neuralgic amyotrophy
Kuhlenbaumer G, et al.
Nature Genetics, 37(10), 1044-1044 (2005)
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