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Merck
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SAB4200190

Anti-Sumo-2/3 antibody, Rat monoclonal

clone 3H12, purified from hybridoma cell culture

Synonym(s):

Anti-HSMT3, Anti-MGC117191, Anti-SMT3 homolog 2, Anti-SMT3 suppressor of mif two 3 homolog 2, Anti-SMT3B, Anti-SMT3H2, Anti-sentrin 2, Anti-small ubiquitin-like modifier 2, Anti-small ubiquitin-related modifier 2, Anti-ubiquitin-like protein SMT3B, Monoclonal Anti-Sumo-2/3, SUMO-2/3, SUMO2/3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03455941

Key Documents

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Product Name

Anti-Sumo-2/3 antibody, Rat monoclonal, clone 3H12, purified from hybridoma cell culture

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

3H12, monoclonal

form

buffered aqueous solution

mol wt

~11 kDa

species reactivity

mouse, rat, human

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
western blot: 2-4 μg/mL using HeLa cell nuclear extract

UniProt accession no.

P55854

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SUMO3(6612)
mouse ... Sumo3(20610)
rat ... Sumo3(499417)

General description

Monoclonal Anti-Sumo-2/3 (rat IgG2a isotype) is derived from the hybridoma 3H12 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a human SUMO3 fusion protein.
Small ubiquitin-like modifier 3 (SUMO3) is encoded by the gene mapped to human chromosome 21q22.3. The protein belongs to the ubiquitin-like protein family and is expressed mainly in cytoplasm.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Application

Monoclonal Anti-Sumo-2/3 has been used in immunoblotting and immunocytochemistry.

Biochem/physiol Actions

Small ubiquitin-like modifier (SUMO) was identified as a post-translational protein modifier.
Small ubiquitin-like modifier 3 (SUMO3) plays a vital role in enhancing cellular responses to environmental stress. It acts as a key element of the leukemogenic network in transient myeloproliferative disorder (TMD) of the newborn/acute megakaryoblastic leukaemia (AMKL).

Immunogen

human SUMO3 fusion protein

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000128396
0000128396
0000108941
070M4777

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A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL
Haemmerling S
British Journal of Haematology, 157, 180-187 (2012)
The Small Ubiquitin-Like Modifier (SUMO) and SUMO-Conjugating System of Chlamydomonas reinhardtii
Wang Y, et al.
Genetics, 179(1), 177-177 (2008)
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.
Saitoh H and Hinchey J.
The Journal of Biological Chemistry, 275, 6252-6258 (2000)
SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.
Castoralova M
Biochimica et Biophysica Acta, 1823, 911-919 (2012)
Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
Su HL and Li SS
Gene, 296, 65-73 (2002)
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