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SAB4200177

Sigma-Aldrich

Anti-SORBS2 antibody, Mouse monoclonal

clone S13N, purified from hybridoma cell culture

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Synonym(s):
Anti-ARGBP2, Anti-Arg binding protein 2; Arg/Abl-interacting protein 2, Anti-Sorbin and SH3 domain containing 2
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

S13N, monoclonal

form

buffered aqueous solution

mol wt

antigen ~85 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
western blot: 5-10 μg/mL using HeLa total cell extracts

isotype

IgG1

UniProt accession no.

O94875

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SORBS2(8470)

General description

SORBS2 or ArgBP2 is an adapter protein that regulates actin-dependent cell adhesion and migration. ArgBP2 facilitates the ubiquitination and degradation of c-Abl. In heart muscle cells, ArgBP2 is localized at Z-disks of sarcomeres and may regulate elasticity of cardiac sarcomeres, whereas in the epithelial cells ArgBP2 may modulate the assembly of signaling complexes in stress fibers . Anti-SORBS2 antibody is specific for human SORBS2 (85 kDa). Staining of the SORBS2 band in immunoblotting is specifically inhibited with the immunizing peptide.

Immunogen

synthetic peptide corresponding to amino acids 29-46 of human SORBS2, conjugated to KLH.

Application

Anti-SORBS2 antibody is suitable for use in western blot (5-10 μg/mL using HeLa total cell extracts) and immunocytochemistry.

Physical form

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Julie Roignot et al.
Cell adhesion & migration, 3(2), 167-170 (2009-03-06)
ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is
B Wang et al.
The Journal of biological chemistry, 272(28), 17542-17550 (1997-07-11)
Arg and c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases. A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system. ArgBP2 contains three COOH-terminal
Philippe Soubeyran et al.
The Biochemical journal, 370(Pt 1), 29-34 (2002-12-12)
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted

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