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SAB4200117

Sigma-Aldrich

Anti-Coronin-1C (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

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Synonym(s):
Anti-CORO1C, Anti-Coronin-1C (C-terminal region), Anti-Coronin-3 (mouse), Anti-HCRNN4
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

packaging

antibody small pack of 25 μL

concentration

~1.5 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using NIH3T3 cells
western blot: 1.5-3.0 μg/mL using A431 cell extract

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CORO1C(23603)
mouse ... Coro1c(23790)
rat ... Coro1c(501841)

General description

Coronin-1C (also known as CORO1C, Coronin-3, HCRNN4) belongs to the coronin family of tryptophan-aspartic acid (WD) 40 repeat-containing proteins. Coronin-1C is ubiquitously expressed and co-localizes with F-actin. In fibroblasts, CORO1C is localized both in the cytosol and in the submembrane cytoskeleton, especially at lamellipodia and membrane ruffles.

Application

Anti-Coronin-1C (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Coronins appear to function primarily in association with the membrane cytoskeleton through interaction with F-actin and the actin-related protein (Arp2/3) complex. They localize to submembrane areas and regulate cell motility and cytoskeletal rearrangement. important in cytokinesis, cell motility, endocytosis, axonal growth, wound healing and signal transduction by altering actin dynamics. Coronin-1C is abundantly expressed in the central nervous system (CNS) during embryogenesis and first postnatal stages and in primary oligodendrocytes.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking
Rybakin V and Clemen CS
Bioessays, 27(6), 625-632 (2005)
Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins
Iizaka M, et al.
Cytogenetic and genome research, 88(3-4), 221-224 (2000)
Coronin 3 and its role in murine brain morphogenesis
Hasse A, et al.
The European Journal of Neuroscience, 21(5), 1155-1168 (2005)
Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus
Spoerl Z, et al.
The Journal of Biological Chemistry, 277(50), 48858-48867 (2002)
Coronin 3 involvement in F-actin-dependent processes at the cell cortex
Rosentreter A, et al.
Experimental Cell Research, 313(5), 878-895 (2007)

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