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SAB4200034

Sigma-Aldrich

Anti-BMI1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-B lymphoma Mo-MLV insertion region 1 homolog, Anti-PCGF4, Anti-Polycomb group RING finger protein 4, Anti-RNF51, Anti-Ring finger protein 51

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200 μL
¥3,890.75

¥3,890.75


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200 μL
¥3,890.75

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

¥3,890.75


Please contact Customer Service for Availability

Request a Bulk Order

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~37 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

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This Item
HPA030472SAB4200033PLA0208
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

-

General description

Anti-BMI1 (C-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the C-terminal of human BMI1, conjugated to KLH. The human proto-oncogene BMI1 (also known as polycomb complex protein BMI-1, polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

Application

Anti-BMI1 (C-terminal) antibody produced in rabbit has been used in:
  • western blotting[1]
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Bmi1, stem cells, and senescence regulation
    Park IK, et al.
    The Journal of Clinical Investigation, 113(2), 175-179 (2004)
    Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    Park I K, et al.
    Nature, 423(6937), 302-302 (2003)
    Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways
    Datta S, et al.
    Cancer Research, 67(21), 10286-10295 (2007)
    Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    Molofsky AV, et al.
    Nature, 425(6961), 962-962 (2003)
    Zhaocheng Zhang et al.
    Cancer research, 74(10), 2869-2881 (2014-04-02)
    Emerging evidence suggests that endothelial cell-secreted factors contribute to the pathobiology of squamous cell carcinoma (SCC) by enhancing invasive migration and resistance to anoikis. Here, we report that SCC cells within the perivascular niche have undergone epithelial to mesenchymal transition

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