SAB4200016
Anti-SLC9A1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-APNH, Anti-NHE1, Anti-Na-Li counter transporter, Anti-Porter, Sodium-hydrogen ion, amiloride-sensitive, Anti-Sodium/hydrogen exchanger 1, Anti-Solute carrier family 9, Isoform A1, Anti-Solute carrier family 9, member 1
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~95 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
western blot: 2.5-5.0 μg/mL using whole extract of human platelets
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC9A1(6548)
General description
The solute carrier family 9 member A1 (SLC9A1) gene is mapped to human chromosome 1p36.11. The encoded protein is widely expressed in many tissues and is localized to the plasma membrane. SLC9A1 is the only isoform found in mammalian cardiomyocytes. This gene encodes a 815 amino acid protein containing 12 transmembrane spanning domain and a cytoplasmic domain with many regulatory sites.
Application
Anti-SLC9A1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Solute carrier family 9 member A1 (SLC9A1) mediates the electroneutral exchange of Na+-H+ in response to intracellular acidosis. It drives extracellular Na+ uptake in exchange for intracellular H+. SLC9A1 maintains the pH and cell volume regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters and cell shrinkage.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
Gazmuri R, et al.
Molecules (Basel), 24(9), 1765-1765 (2019)
CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis
Liu Ye, et al.
The Journal of Neuroscience, 33(31), 12656-12669 (2013)
Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule
Parker MD, et al.
Cellular and Molecular Life Sciences, 72(11), 2061-2074 (2015)
Physiological functions and regulation of the Na+/H+ exchanger [NHE1] in renal tubule epithelial cells
Valles PG, et al.
Kidney & Blood Pressure Research, 40(5), 452-466 (2015)
Naoko Fujii et al.
The Journal of biological chemistry, 291(47), 24787-24799 (2016-10-14)
Hypotonic stress decreased claudin-1 and -2 expression levels in renal tubular epithelial HK-2 and Madin-Darby canine kidney cells. Here, we examined the regulatory mechanism involved in this decrease. The hypotonicity-induced decrease in claudin expression was inhibited by the following: SB202190
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