SAB4200005
Anti-UVRAG antibody ,Mouse monoclonal
clone UVRAG-11, purified from hybridoma cell culture
Synonym(s):
Anti-DHTX, Anti-UV radiation resistance-associated gene protein, Anti-p63
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-UVRAG antibody ,Mouse monoclonal, clone UVRAG-11, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
UVRAG-11, monoclonal
form
buffered aqueous solution
mol wt
antigen ~90 kDa
species reactivity
mouse, human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): suitable
western blot: 2-4 μg/mL using whole extract of human G361 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UVRAG(7405)
mouse ... Uvrag(78610)
Biochem/physiol Actions
Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.
UVRAG is positive regulator of the Beclin 1- class III phosphatidylinositol 3-kinase (PI(3)KC3) complex. The tumor suppressor Beclin 1 forms a complex with PI(3)KC3, promoting autophagosome formation. UVRAG interacts with Beclin 1 through their coiled-coil domains and induces autophagy resultin in suppression of proliferation and tumorigenicity of human colon cancer cells. UVRAG is a tumor suppressor candidate.
Application
Monoclonal Anti-UVRAG antibody produced in mouse has been used in immunoprecipitation.
Monoclonal Anti-UVRAG antibody produced in mouse has been used in western blotting and immunohistochemistry.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-UVRAG, UV radiation resistance associated gene, complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppres
Monoclonal Anti-UVRAG (mouse IgG1 isotype) is derived from the hybridoma UVRAG-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human UVRAG.
Ultraviolet irradiation resistance-associated gene (UVRAG) is a crucial autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a Beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis
Nature (2012)
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Yin X
EMBO Reports (2011)
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Liang C, et al.
Nature Cell Biology, 8(7), 688-688 (2006)
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
Shanshan He
Nature Communications (2015)
Kenta Kuramoto et al.
Cell reports, 35(8), 109184-109184 (2021-05-27)
Autophagy dysregulation is implicated in metabolic diseases, including type 2 diabetes. However, the mechanism by which the autophagy machinery regulates metabolism is largely unknown. Autophagy is generally considered a degradation process via lysosomes. Here, we unveil a metabolically important non-cell-autonomous
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