Anti-POU1F1/PIT1 antibody produced in rabbit

POU1F1 is encoded by the gene mapped to human chromosome 3p11.2.

Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is a pituitary-specific transcription factor and is a member of the POU family of transcription factors.

Anti-POU1F1/PIT1 recognizes human POU1F1/PIT1.

Anti-POU1F1/PIT1 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is responsible for pituitary development and hormone expression in mammals. It regulates mammalian development. POU1F1/PIT1 is required for the differentiation and proliferation of the anterior pituitary somatotrophs, lactotrophs and thyrotrophs cell lineages. Mutation in Pit-1 gene is associated with the syndrome of combined pituitary hormone deficiency (CPHD), a disease characterized by the lack of prolactin, growth hormone and thyroid stimulating hormone β. POU1F1/PIT1 regulates its target gene expression by binding to response elements on their promoter regions and recruitment of co-regulatory proteins, that alter histone acetylation and modify chromatin structures.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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