Monoclonal Anti-LOX antibody produced in mouse

Monoclonal Anti-LOX (mouse IgG1 isotype) is derived from the hybridoma LOX-A11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human LOX recombinant protein.

The gene LOX (lysyl oxidase) encodes a copper-dependent amine oxidase that belongs to LOX family of proteins. These proteins contain highly conserved C- terminal mature catalytic domains that include the copper binding site, the lysyl tyrosyl quinine (LTQ) cofactor residues, and the cytokine receptor like (CRL) domain. It is present in both intercellular and intracellular locations.

LOX purified recombinant protein

Monoclonal Anti-LOX antibody produced in mouse has been used in:

• immunoblotting
• flow cytometry
• immunofluorescence

The gene LOX (lysyl oxidase) encodes an extracellular matrix remodeling enzyme that catalyzes the oxidation of primary amino group of peptidyl lysine to reactive peptidyl aldehydes. It is mainly involved in the oxidation of lysine residues in elastin and collagen, resulting in the formation of covalent cross-linkages, which stabilize these fibrous proteins. It also plays a role in several cellular processes such as developmental regulation, tumor suppression, cell motility, and cellular senescence. It is involved in hypoxia-induced metastasis and serves as a therapeutic target for the treatment of metastases.

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

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