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Safety Information

SAB2106287

Sigma-Aldrich

Anti-ARPC4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ARC20, Anti-P20-ARC

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

20 kDa

species reactivity

rat, bovine, dog, human, rabbit, horse, guinea pig, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NM_026552

UniProt accession no.

P59999

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARPC4(10093)
mouse ... Arpc4(68089)

Related Categories

Immunogen

Synthetic peptide directed towards the N terminal of human ARPC4

Biochem/physiol Actions

Arpc4 functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Sequence

Synthetic peptide located within the following region: AVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEK

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Cristiane J Nunes-Santos et al.
Nature communications, 14(1), 3708-3708 (2023-06-23)
We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset autoimmunity, inflammation, and dysmorphisms. This defect compromises multiple cell lineages

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