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Safety Information

SAB2103443

Sigma-Aldrich

Anti-CSRP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CRP, Anti-CRP1, Anti-CSRP, Anti-CYRP, Anti-D1S181E

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250 MG
CN¥1,245.18
1 G
CN¥3,260.71
5 G
CN¥10,782.06
25 G
CN¥22,395.62

CN¥1,245.18

In StockDetails

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250 MG
CN¥1,245.18
1 G
CN¥3,260.71
5 G
CN¥10,782.06
25 G
CN¥22,395.62

About This Item

MDL number:
MFCD00162183
UNSPSC Code:
12352203
NACRES:
NA.41

CN¥1,245.18

In StockDetails

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

20 kDa

species reactivity

rat, human, dog, guinea pig, rabbit, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

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application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

form

solid

form

solid

form

powder

form

solid

composition

Dye, ≥60% spectrophotometric assay

composition

Dye, ≥60% spectrophotometric assay

composition

Dye content, ≥60%

composition

Dye, ≥50% spectrophotometric assay

εmax

≥1500 at 623-628 nm in 50% ethanol at 0.005 g/L

εmax

-

εmax

-

εmax

≥810 at 630-635 nm in water at 0.005 g/L

Quality Level

400

Quality Level

200

Quality Level

200

Quality Level

400

General description

Cysteine and glycine rich protein 1 (CSRP1) is expressed in smooth muscles. The gene is located on human chromosome 1q32.1.

Immunogen

Synthetic peptide directed towards the middle region of human CSRP1

Biochem/physiol Actions

Cysteine and glycine rich protein 1 (CSRP1) is a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Other genes in the family include CSRP2 and CSRP3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
LIM domain of CSRP1 is involved in smooth muscle differentiation and protein dimerization. CSRP1 modulates actin filament bundling. It acts as a stress response factor and is involved in growth inhibitory and cytoprotective functions.

Sequence

Synthetic peptide located within the following region: YGYGQGAGTLSTDKGESLGIKHEEAPGHRPTTNPNASKFAQKIGGSERCP

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    QC11625

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    Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death
    Latonen L, et al.
    Experimental Cell Research, 314(4), 738-747 (2008)
    The LIM/double zinc-finger motif functions as a protein dimerization domain
    Feuerstein R, et al.
    Proceedings of the National Academy of Sciences of the USA, 91(22), 10655-10659 (1994)
    Päivi M Järvinen et al.
    Journal of cellular physiology, 227(6), 2605-2612 (2011-09-02)
    Transforming growth factor-β (TGF-β) is a diverse cytokine regulating growth, apoptosis, differentiation, adhesion, invasion, and extracellular matrix production. Dysregulation of TGF-β is associated with fibrotic disorders and epithelial-mesenchymal transition, and has been linked with idiopathic pulmonary fibrosis (IPF). Cysteine-rich protein
    Epigenetics Offer New Horizons for Colorectal Cancer Prevention.
    Schnekenburger M and Diederich M
    Current Colorectal Cancer Reports, 8(1), 66-81 (2012)

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