SAB2103443
Anti-CSRP1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-CRP, Anti-CRP1, Anti-CSRP, Anti-CYRP, Anti-D1S181E
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
20 kDa
species reactivity
rat, human, dog, guinea pig, rabbit, mouse
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CSRP1(1465)
General description
Cysteine and glycine rich protein 1 (CSRP1) is expressed in smooth muscles. The gene is located on human chromosome 1q32.1.
Immunogen
Synthetic peptide directed towards the middle region of human CSRP1
Biochem/physiol Actions
Cysteine and glycine rich protein 1 (CSRP1) is a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Other genes in the family include CSRP2 and CSRP3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
LIM domain of CSRP1 is involved in smooth muscle differentiation and protein dimerization. CSRP1 modulates actin filament bundling. It acts as a stress response factor and is involved in growth inhibitory and cytoprotective functions.
LIM domain of CSRP1 is involved in smooth muscle differentiation and protein dimerization. CSRP1 modulates actin filament bundling. It acts as a stress response factor and is involved in growth inhibitory and cytoprotective functions.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: YGYGQGAGTLSTDKGESLGIKHEEAPGHRPTTNPNASKFAQKIGGSERCP
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The LIM/double zinc-finger motif functions as a protein dimerization domain
Feuerstein R, et al.
Proceedings of the National Academy of Sciences of the USA, 91(22), 10655-10659 (1994)
Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death
Latonen L, et al.
Experimental Cell Research, 314(4), 738-747 (2008)
Päivi M Järvinen et al.
Journal of cellular physiology, 227(6), 2605-2612 (2011-09-02)
Transforming growth factor-β (TGF-β) is a diverse cytokine regulating growth, apoptosis, differentiation, adhesion, invasion, and extracellular matrix production. Dysregulation of TGF-β is associated with fibrotic disorders and epithelial-mesenchymal transition, and has been linked with idiopathic pulmonary fibrosis (IPF). Cysteine-rich protein
Epigenetics Offer New Horizons for Colorectal Cancer Prevention.
Schnekenburger M and Diederich M
Current Colorectal Cancer Reports, 8(1), 66-81 (2012)
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