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Safety Information

SAB2102328

Sigma-Aldrich

Anti-STUB1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CHIP, Anti-HSPABP2, Anti-NY-CO-7, Anti-SDCCAG7, Anti-STIP1 homology and U-box containing protein 1

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About This Item

MDL number:
MFCD02262541
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

35 kDa

species reactivity

horse, rat, bovine, human, dog, guinea pig, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

Q9UNE7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... STUB1(10273)

General description

STUB1 (STIP1 homology and U-box containing protein 1) codes for CHIP (C-terminus of HSC70-interacting protein). It is located on human chromosome 16p13.3.

Immunogen

Synthetic peptide directed towards the C terminal region of human STUB1

Biochem/physiol Actions

STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates the transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Mutations in STUB1 (STIP1 homology and U-box containing protein 1) result in autosomal recessive cerebellar ataxia (ARCA). The carboxyl terminus of the Hsc70?interacting protein (CHIP) has the ability to stimulate ubiquitination and degradation of various oncogenic proteins. It also plays a vital role in blocking tumor progression and invasion.

Sequence

Synthetic peptide located within the following region: VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHF

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC13236

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STUB1/CHIP mutations cause Gordon Holmes syndrome as part of a widespread multisystemic neurodegeneration: evidence from four novel mutations
Hayer SN, et al.
Orphanet Journal of Rare Diseases, 12(1), 31-31 (2017)
Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer
Kurozumi S, et al.
Cancer Medicine, 5(8), 1873-1882 (2016)
Choreoathetosis, dystonia, and myoclonus in 3 siblings with autosomal recessive spinocerebellar ataxia type 16
Kawarai T, et al.
JAMA Neurology, 73(7), 888-890 (2016)

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