SAB2102031
Anti-RNF31 antibody produced in rabbit
affinity isolated antibody
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Anti-FLJ10111, Anti-FLJ23501, Anti-MGC19975, Anti-Ring finger protein 31, Anti-ZIBRA
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
120 kDa
species reactivity
rabbit, guinea pig, rat, human
packaging
pkg of 100 μL buffered aqueous solution
pkg of 50 μg lyophilized powder
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RNF31(55072)
Immunogen
Synthetic peptide directed towards the middle region of human RNF31
Application
Anti-RNF31 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
PWP2 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
Sequence
Synthetic peptide located within the following region: SLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKL
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
PLoS ONE, 8(10), 1-9 (2013)
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature Communications, 7:12547, 1-14 (2016)
SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes.
The Embo Journal, 35(17), 1868-1884 (2016)
Scientific reports, 14(1), 346-346 (2024-01-04)
RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κB) pathway via the generation of
Nature communications, 7, 12547-12547 (2016-08-25)
Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear.
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