SAB2101415
Anti-MAFB antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
Anti-KRML, Anti-MGC43127, Anti-V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
36 kDa
species reactivity
human, rat, guinea pig, horse, bovine, mouse, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAFB(9935)
General description
MAF bZIP transcription factor B (MAFB) is encoded by the gene mapped to human chromosome 20q12. The encoded protein is a member of the maf oncogene family and is ubiquitously expressed in variety of tissues. MAFB is a 311 amino acid protein characterized with a typical basic leucine zipper (bZIP) domain in its C-terminal region.
Immunogen
Synthetic peptide directed towards the N terminal region of human MAFB
Biochem/physiol Actions
MAF bZIP transcription factor B (MAFB) has been implicated in the development of the hindbrain structures, thymus, interneurons, pancreatic islet cells and the hematopoietic system. In mouse, it helps in lip and palate development. MAFB regulates lineage-specific gene expression by suppressing the Ets-1-mediated transcription. The encoded protein plays an essential role in islet α-cell function. In addition, MAFB also regulates genes involved in both endocrine α- and β-cell differentiation. The protein acts as a modulator and marker of adipose tissue inflammation. Mutations in the gene is associated with the development of multicentric carpo-tarsal osteolysis (MCTO).
Sequence
Synthetic peptide located within the following region: APQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPE
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
MAFB as a novel regulator of human adipose tissue inflammation.
Pettersson AM
Diabetologia, 58, 2115-2123 (2015)
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Artner I
Diabetes, 55, 297-304 (2006)
The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability.
Mehawej C
American Journal of Medical Genetics. Part A, 161A, 3023-3029 (2013)
MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation
Sieweke MH
Cell, 85, 49-60 (1996)
MafB, a New Maf Family Transcription Activator That Can
Associate with Maf and Fos but Not with Jun
Kataoka K
Molecular and Cellular Biology, 14, 7581-7591 (1994)
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