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SAB1405428

Sigma-Aldrich

Anti-ADFP antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

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Synonym(s):
ADRP, MGC10598
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~48.1 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_001122.2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADFP(123)

General description

Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation (provided by RefSeq)
Adipose differentiation-related protein (ADRP), also known as adipose differentiation-related protein (ADFP), is the major lipid droplet protein. It is encoded by the gene mapped to human chromosome 9p22.1–p21.3. ADFP is ubiquitously expressed and is a member of PAT (perilipin/APRP/TIP47) family.

Immunogen

ADFP (NP_001113.2, 1 a.a. ~ 437 a.a) full-length human protein.

Sequence
MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH

Biochem/physiol Actions

Adipose differentiation-related protein (ADFP) plays a vital role in lipid droplet (LD) formation and/or maturation. Increased expression of this protein in tamm-horsfall protein 1 (THP-1) macrophages increases lipid accumulation and stops lipid efflux. In addition, ADFP is slightly involved in maintenance of adipose tissue homeostasis. It acts as a potential marker for intracellular LD in tissues.

Physical form

Solution in phosphate buffered saline, pH 7.4

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line
Sztalryd C, et al.
The Journal of Biological Chemistry, 281(45), 34341-34348 (2006)
Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization
Qiu J, et al.
Biochemical and Biophysical Research Communications, 352(2), 469-478 (2007)
Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease
Chang BHJ, et al.
The American Journal of Physiology, 292(6), G1465-G1468 (2007)

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