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SAB1402959

Sigma-Aldrich

Monoclonal Anti-VCAM1 antibody produced in mouse

clone 1H6, purified immunoglobulin, buffered aqueous solution

Synonym(s):

CD106, DKFZp779G2333, INCAM-100, MGC99561

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1H6, monoclonal

form

buffered aqueous solution

mol wt

antigen ~107.4 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2bκ

NCBI accession no.

BC017276

UniProt accession no.

P19320

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VCAM1(7412)

General description

Vascular cell adhesion molecule 1 (VCAM1) is activated by transforming growth factor β-1 (TGF-β1) and is part of the immunoglobulin superfamily. The protein is expressed in blood vessels. VCAM1 possesses many extracellular immunoglobulin-like domains, a transmembrane region and a cytoplasmic domain. The gene encoding it is localized on human chromosome 1p21.2.

Immunogen

VCAM1 (AAH17276, 1 a.a. ~ 739 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV

Biochem/physiol Actions

Vascular cell adhesion molecule 1 (VCAM1) plays a role in the adhesion of monocytes, lymphocytes, basophils and eosinophils to the vascular endothelium. It also functions in signal transduction and adhesion of leukocytes to endothelial cells. The protein has been associated with atherosclerosis and rheumatoid arthritis. VCAM1 is upregulated in idiopathic pulmonary fibrosis.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pharmacogenomics of Multigenic Diseases: Sex-Specific Differences in
Disease and Treatment Outcome
Julia Pinsonneault
AAPS PharmSci (2003)
Vascular cell adhesion molecule-1 (VCAM-1)--an increasing insight into its role in tumorigenicity and metastasis.
Schlesinger M and Bendas G
International Journal of Cancer. Journal International Du Cancer (2015)
VCAM-1 is a TGF-?1 inducible gene upregulated in idiopathic pulmonary fibrosis.
Agassandian M
Cellular Signalling (2015)

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