SAB1306611
ANTI-LC3 (APG8B) (N-TERM) antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
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Synonym(s):
Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1ALC3, MAP1LC3B, Microtubule-associated proteins 1A/1B light chain 3B
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
14688 Da
species reactivity
human, rat
technique(s)
immunofluorescence: 1:100
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAP1LC3B(81631)
General description
The gene LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 beta) is a homolog of the ATG8 gene, an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I.
Biochem/physiol Actions
MAP1LC3B-I (microtubule associated protein 1 light chain 3 beta-I) conjugates with MAP1LC3B-II before being inserted into both inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. It can serve as an autophagic marker.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
Swaminathan B, et al.
PLoS ONE (2014)
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, et al.
The Journal of Clinical Investigation, 120(1), 127-141 (2010)
Anna Churilova et al.
International journal of molecular sciences, 23(14) (2022-07-28)
Autophagy is a regulated mechanism of degradation of misfolded proteins and organelles in the cell. Neurons are highly differentiated cells with extended projections, and therefore, their functioning largely depends on the mechanisms of autophagy. For the first time in an
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