SAB1306537
ANTI-BECLIN1-BH3 DOMAIN antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Synonym(s):
BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
51896 Da
species reactivity
human, mouse
technique(s)
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BECN1(8678)
Related Categories
General description
Beclin 1 (BECN1) is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.
Application
ANTI-BECLIN1-BH3 DOMAIN antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
Beclin 1 (BECN1) acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, et al.
Nature, 545, 108-111 (2017)
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Hu Z, et.al
Molecular Medicine Reports, 14(2), 1567-1573 (2016)
Role of Autophagy in Breast Cancer
Vassiliki Karantza & Eileen White
Autophagy (2007)
Class III phosphoinositide 3-kinase?Beclin1 complex mediates the amino
acid-dependent regulation of autophagy in C2C12 myotubes
acid-dependent regulation of autophagy in C2C12 myotubes
BioChemistry: An Indian Journal (2003)
RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-?-Catenin Pathway in Glutamate Excitotoxicity Injury
Yuefan Yang
Frontiers in Cellular Neuroscience (2017)
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