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Merck
CN

SAB1306484

ANTI-BECLIN 1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

51896 Da

species reactivity

mouse, human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

NP_003757.1

UniProt accession no.

Q14457

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BECN1(8678)

Related Categories

General description

Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.

Application

ANTI-BECLIN 1 antibody produced in rabbit has been used for Western blotting.

Biochem/physiol Actions

Beclin 1 (BECN1) or GT197 acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
SH050527I
SA110923AU

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The BECN1 N-terminal domain is intrinsically disordered.
Autophagy (2016)
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, et al.
Nature (2017)
Class III phosphoinositide 3-kinase?Beclin1 complex mediates the amino
acid-dependent regulation of autophagy in C2C12 myotubes
Amina TASSA, et al.
BioChemistry: An Indian Journal (2003)
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Hu Z, et al.
Molecular Medicine Reports (2016)
CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a
Ai-Gang Sun, et al.
Molecular Medicine Reports (2017)
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