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SAB1306281

Sigma-Aldrich

ANTI-SNAIL (N-TERM D24) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Protein snail homolog 1, SNAH, SNAI1, Zinc finger protein SNAI1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

29083 Da

species reactivity

human

technique(s)

immunohistochemistry: 1:10-1:50
western blot: 1:1000

NCBI accession no.

NP_005976.2

UniProt accession no.

O95863

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNAI1(6615)

General description

Snail family transcriptional repressor 1 (SNAIL) is a transcription factor and the gene encoding it is localized on human chromosome 20q13.13.

Application

ANTI-SNAIL (N-TERM D24) antibody produced in rabbit has been used in Western Blotting.

Biochem/physiol Actions

Snail family transcriptional repressor 1 (SNAIL) acts as a repressor of genes associated with the epithelial phenotype like E-cadherin and increases the expression of genes linked with the mesenchymal phenotype. It has a role in epithelial-mesenchymal transition. The protein aids in G1 transition (early to late) in the cell cycle. SNAIL also modulates cell-matrix adhesion.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells.
Haraguchi M
PLoS ONE, 10(7) (2015)
TP53 Mutation, Epithelial-Mesenchymal Transition, and StemlikeFeatures in Breast Cancer Subtypes
Danila Coradini
Journal of Biomedicine and Biotechnology (2013)
SNAIL transcription factor increases the motility and invasive capacity of prostate cancer cells.
Osorio LA
Molecular Medicine Reports, 13(1), 778-786 (2016)
Sharleen V Menezes et al.
Carcinogenesis, 40(6), 805-818 (2018-12-19)
The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhibited the oncogenic effects of transforming growth factor-β (TGF-β)
Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer
Wang Yan
Experimental and Therapeutic Medicine, 2830-2836 (2018)
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