SAB1305652
ANTI-CD11B(N-TERMINAL) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Synonym(s):
CD11 antigen-like family member B, CD11B, CR3A, ITGAM, Integrin alpha-M
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
127179 Da
species reactivity
human
technique(s)
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGAM(3684)
Related Categories
General description
Cluster of differentiation 11b (CD11b), also known as integrin subunit α M (ITGAM), is encoded by the gene mapped to human chromosome 16p11.2. It belongs to the integrin α chain family. CD11b is expressed by a variety of myeloid cell types, such as dendritic cells, macrophages, monocytes and neutrophils.
Biochem/physiol Actions
Cluster of differentiation 11b (CD11b) acts as a receptor for complement component C3 degradation product, iC3b. CD11b interacts with β2 chain (ITGB2) to form a leukocyte integrin (MAC-1 or complement receptor 3 (CR3)), which in turn plays a crucial role in adherence of neutrophils and monocytes to stimulated endothelium. Mutation in the gene increases the risk of susceptibility to systemic lupus erythematosus (SLE) and acute inflammatory demyelinating polyradiculoneuropathy (AIDP).
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Association of Systemic Lupus Erythematosus with C8orf13?BLK and ITGAM?ITGAX
Geoffrey Hom,et al.
New. J. Chem. (2008)
The pathogenic relevance of aM-integrin in Guillain-Barre syndrome.
Acta Neuropathologica (2016)
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Harley JB, et al.
Nature Genetics (2008)
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nath SK, et al.
Nature Genetics (2008)
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