SAB1305503
MONOCLONAL ANTI-CD25 antibody produced in mouse
clone 7G7B6, crude ascites, buffered aqueous solution
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Synonym(s):
CD_antigen=CD25, IL2RA, Interleukin-2 receptor subunit alpha, TAC antigen, p55
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
mouse
antibody form
crude ascites
antibody product type
primary antibodies
clone
7G7B6, monoclonal
form
buffered aqueous solution
mol wt
30819 Da
species reactivity
human
technique(s)
western blot: 1:100-~1:800
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IL2RA(3559)
General description
The CD25 gene, also referred to as IL2RA (interleukin 2 receptor subunit α), is mapped to human chromosome 10p15. The gene spans a length of 48 kb with eight exons.
Biochem/physiol Actions
The interleukin 2 receptor subunit α (IL2RA) gene encodes the α-chain of the IL-2 receptor complex. This receptor complex, made up of α, β, and a common γ chain, binds to its ligand, IL-2, which is a crucial growth factor for T- and B-cells. This ligand-receptor complex plays an important role in the regulation of immune responses. Variation in the chromosomal region containing this gene is associated with type 1 diabetes. This region is also linked to autoimmune thyroid disease indicating its role in autoimmunity. IL2RA has been found to confer a risk for multiple sclerosis.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
Weber F, et al.
Genes and Immunity, 9(3), 259-259 (2008)
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
Maier L M, et al.
PLoS Genetics, 5(1), e1000322-e1000322 (2009)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Lowe C E, et al.
Nature Genetics, 39(9), 1074-1074 (2007)
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Qu H Q, et al.
Diabetes, 56(4), 1174-1176 (2007)
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