SAB1300170
Anti-SUMO4 (M55 Wild type) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
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Synonym(s):
Anti-SMT3 suppressor of mif two 3 homolog 2, Anti-SMT3H4, Anti-SUMO-4, Anti-Small ubiquitin-like modifier 4, Anti-Small ubiquitin-like protein 4
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
saturated ammonium sulfate (SAS) precipitated
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SUMO4(387082)
General description
SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins′ subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes. This antibody is generated from rabbits immunized with the KLH conjugated peptide CEPRGLS(M)KQIRFRFG selected from human SUMO4. This antibody is peptide affinity purified using peptides CEPRGLS(M)KQIRFRFG (positive selection) and CEPRGLS(V)KQIRFRFG (negative selection).
Immunogen
SUMO4 (NP_001002255, )
This antibody is generated from rabbits immunized with the KLH conjugated peptide CEPRGLS(M)KQIRFRFG selected from human SUMO4. This antibody is peptide affinity purified using peptides CEPRGLS(M)KQIRFRFG (positive selection) and CEPRGLS(V)KQIRFRFG (negative selection).
This antibody is generated from rabbits immunized with the KLH conjugated peptide CEPRGLS(M)KQIRFRFG selected from human SUMO4. This antibody is peptide affinity purified using peptides CEPRGLS(M)KQIRFRFG (positive selection) and CEPRGLS(V)KQIRFRFG (negative selection).
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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