S9947
Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat
clone 55626, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
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About This Item
NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
55626, monoclonal
Application:
WB
Citations:
4
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
55626, monoclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
western blot: 1-2 μg/mL
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Shh(20423)
Immunogen
purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog C-terminal peptide (aa 199-437).
Biochem/physiol Actions
Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb, and axon guidance factors during the development of brain and nervous system.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Alessia Omenetti et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(3), G595-G598 (2008-01-26)
Hedgehog (Hh) signaling modulates tissue remodeling by controlling the fate of Hh-responsive cells. Healthy adult livers exhibit little Hh activity. However, cells involved in adult liver repair, including myofibroblasts and progenitors, are capable of producing and responding to Hh ligands.
Aileen Rivell et al.
Biology open, 8(3) (2019-03-07)
Beyond its role in patterning the neural tube during embryogenesis, additional functions of Sonic hedgehog (Shh) in post-embryonic and mature brains have been coming into focus. However, the question of the abundance of endogenous Shh - the ligand of the
Fergal C Kelleher
Carcinogenesis, 32(4), 445-451 (2010-12-28)
To conduct a systematic review of the role that the hedgehog signaling pathway has in pancreatic cancer tumorigenesis. PubMed search (2000-2010) and literature based references. Firstly, in 2009 a genetic analysis of pancreatic cancers found that a core set of
Shohreh F Farzan et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(4), G844-G849 (2008-02-02)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given
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