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S9944

Sigma-Aldrich

Sibutramine hydrochloride monohydrate

≥98% (HPLC), solid

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Synonym(s):
1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil
Empirical Formula (Hill Notation):
C17H26ClN · HCl
CAS Number:
84485-00-7
Molecular Weight:
316.31
MDL number:
MFCD04039806
UNSPSC Code:
12352116
PubChem Substance ID:
329824638
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV

storage condition

desiccated

color

white

solubility

DMSO: >30 mg/mL
H2O: insoluble

originator

Abbott

storage temp.

room temp

SMILES string

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

InChI key

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Application

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.1

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Alexandre V Ivachtchenko et al.
Journal of Alzheimer's disease : JAD, 58(4), 1043-1063 (2017-05-28)
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and
Jenjira Saichanapan et al.
Talanta, 212, 120788-120788 (2020-03-03)
This work presents a new material, i.e., a porous graphene ink to modify on the GCE surface (PGr-ink/GCE) to improve sensitivity by increasing the surface area of the electrode for the electrochemical determination of sibutramine. The surface characterization and electrochemical
Cibele S Borges et al.
PloS one, 8(6), e66091-e66091 (2013-06-19)
Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we
Jamie D Dunn et al.
Journal of pharmaceutical and biomedical analysis, 54(3), 469-474 (2010-10-14)
In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput
Hiroaki Yashiro et al.
PloS one, 11(11), e0166198-e0166198 (2016-11-11)
Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory
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