Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

S9820

Sigma-Aldrich

SU 11274

≥98% (HPLC), powder

Synonym(s):

(3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C28H30ClN5O4S
CAS Number:
658084-23-2
Molecular Weight:
568.09
MDL number:
MFCD08276928
UNSPSC Code:
12352200
PubChem Substance ID:
24724625
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: 10 mg/mL at 60 °C
H2O: insoluble

storage temp.

2-8°C

SMILES string

CN1CCN(CC1)C(=O)c2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(cc34)S(=O)(=O)N(C)c5cccc(Cl)c5)c2C

InChI

1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-

InChI key

FPYJSJDOHRDAMT-KQWNVCNZSA-N

Application

SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3
SU11274 has been used:
  • To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation.
  • To study its effect on human gastric carcinoma cell line MKN-45.
  • To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways.

Biochem/physiol Actions

SU 11274 is a Met tyrosine kinase inhibitor.
SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2
c-Met kinase is a hepatocyte growth factor, involved in tumor invasion process and thus it serves as therapeutic target for cancer. It is found that SU11274 showed decreased tumor progression in human melanoma, by reducing tumor growth and metastasis.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000004020
0000004021
0000002138
072M4606V
050M46041V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Gang Chen et al.
PloS one, 8(3), e59708-e59708 (2013-03-26)
Epidermal growth factor receptor (EGFR) and c-MET receptors are expressed on many non-small cell lung cancer (NSCLC) cells. Current single agent therapeutic targeting of a mutant EGFR has a high efficacy in the clinic, but is not curative. Here, we
Mechanism of resistance and novel targets mediating resistance to EGFR and c-Met tyrosine kinase inhibitors in non-small cell lung cancer
Botting GM, et al.
Testing, 10(8), e0136155-e0136155 (2015)
Anum Mughal et al.
Infectious agents and cancer, 8(1), 13-13 (2013-04-10)
c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor receptor (HGFR). Inappropriate activity of c-Met can cause wide variety of carcinomas. c-Met inhibitor are relatively new class of small molecules that inhibit the enzymatic activity
Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation (2013)
Complementary PTM profiling of drug response in human gastric carcinoma by immunoaffinity and IMAC methods with total proteome analysis
Stokes MP, et al.
Proteome, 3(3), 160-183 (2015)
View All Related Papers

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service