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Merck
CN

S9637

Sodium succinate dibasic hexahydrate

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym(s):

Butanedioic acid disodium salt, Succinic acid disodium salt

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About This Item

Linear Formula:
NaOOCCH2CH2COONa · 6H2O
CAS Number:
6106-21-4
Molecular Weight:
270.14
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
24899848
EC Number:
205-778-7
Beilstein/REAXYS Number:
3921044
MDL number:
MFCD00149117
Solubility:
H2O: 100 mg/mL, clear, colorless

Key Documents

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Product Name

Sodium succinate dibasic hexahydrate, BioReagent, suitable for cell culture, suitable for insect cell culture

InChI key

ZBTUYCUNQBRXOR-UHFFFAOYSA-L

InChI

1S/C4H6O4.2Na.6H2O/c5-3(6)1-2-4(7)8;;;;;;;;/h1-2H2,(H,5,6)(H,7,8);;;6*1H2/q;2*+1;;;;;;/p-2

SMILES string

O.O.O.O.O.O.[Na+].[Na+].[O-]C(=O)CCC([O-])=O

product line

BioReagent

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

pH

8—9.5 (25 °C, 270 g/L)

solubility

H2O: 100 mg/mL, clear, colorless

Quality Level

300

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Application

Sodium succinate dibasic hexahydrate has been used:
  • as a supplement in the assay medium to incubate mitochondria to measure the specific activity of complex-II
  • as a component in plant induction medium/ protoplast induction media (PIM) for plant regeneration
  • as a small-molecule additive in the fresh medium to study its positive synergistic effects on transgene expression in Chinese hamster ovary (CHO) cells

Features and Benefits

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • BioReagent Grade Sodium succinate for your Cell Biology and Biochemical research
  • Tested for Mammalian and Insect cell culture applications

General description

Sodium succinate dibasic hexahydrate is the sodium salt of succinic acid, a dicarboxylic acid. This versatile compound finds extensive use in cell biology, cell culture, and biochemical research applications. It serves as both an energy source and a buffer in cell culture and cell biology research, particularly within the Tricarboxylic Acid (TCA) or Krebs cycle. It is hypothesized that Sodium succinate dibasic hexahydrate acts as an ionophore, facilitating the transport of ions across cell membranes and thus influencing cellular metabolism. Also known as Succinic acid disodium salt, this product provides the necessary substrate for ATP (adenosine triphosphate) production, essential for optimal cellular function.

Other Notes

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7384V
0000500038
0000500038
WXBF7134V
0000484019

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Huimin Mao et al.
Stem cells international, 2020, 2016809-2016809 (2020-03-28)
Most mesenchymal stem cells reside in a niche of low oxygen tension. Iron-chelating agents such as CoCl2 and deferoxamine have been utilized to mimic hypoxia and promote cell growth. The purpose of the present study was to explore whether a
Wei-Feng Li et al.
New biotechnology, 69, 8-17 (2022-02-27)
Chinese hamster ovary (CHO) cells are currently the most widely used host cells for production of recombinant therapeutic proteins (RTPs). Small-molecule additives related to cell cycle apoptosis and autophagy regulation have been used to promote RTP production. By combining two
Jongjin Park et al.
Methods in molecular biology (Clifton, N.J.), 1917, 337-354 (2019-01-06)
CRISPR/Cas9 nuclease system is getting popular in precise genome editing of both eukaryotic and prokaryotic systems due to its accuracy, programmability, and relative ease of use. CRISPR/Cas systems can be delivered into live cells via plasmid DNA, RNA, and ribonucleoprotein
Georgia L Isom et al.
Cell, 181(3), 653-664 (2020-05-04)
Gram-negative bacteria are surrounded by an outer membrane composed of phospholipids and lipopolysaccharide, which acts as a barrier and contributes to antibiotic resistance. The systems that mediate phospholipid trafficking across the periplasm, such as MCE (Mammalian Cell Entry) transporters, have
Adrián Povo-Retana et al.
Cancers, 12(10) (2020-10-24)
Tumor-associated macrophages (TAMs) play a crucial role in suppressing the immunosurveillance function of the immune system that prevents tumor growth. Indeed, macrophages can also be targeted by different chemotherapeutic agents improving the action over immune checkpoints to fight cancer. Here
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