S9381
Succinimide
99.1%
Synonym(s):
2,5-Pyrrolidinedione
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About This Item
Empirical Formula (Hill Notation):
C4H5NO2
CAS Number:
Molecular Weight:
99.09
Beilstein:
108440
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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Product Name
Succinimide,
Assay
99.1%
Quality Level
form
powder or crystals
color
white to off-white
bp
285-290 °C (lit.)
mp
123-125 °C (lit.)
SMILES string
O=C1CCC(=O)N1
InChI
1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
InChI key
KZNICNPSHKQLFF-UHFFFAOYSA-N
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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David Rennison et al.
Bioorganic & medicinal chemistry, 15(8), 2963-2974 (2007-02-27)
Norbormide [5-(alpha-hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. A series of NRB-related analogues were prepared to investigate the structural features responsible for
Jennifer Zhang et al.
Analytical biochemistry, 410(2), 234-243 (2010-12-07)
A thermally stressed Fab molecule showed a significant increase of basic variants in imaged capillary isoelectric focusing (iCIEF) analysis. Mass analyses of the reduced protein found an increase in -18Da species from both light chain and heavy chain. A tryptic
X Christopher Yu et al.
Analytical chemistry, 83(15), 5912-5919 (2011-06-23)
We report an efficient, high fidelity trypsin digestion method for peptide map analysis. This method minimizes artifacts caused by the sample preparation process, and we show its utility for the accurate determination of succinimide formation in a degraded monoclonal antibody
Yann Desfougères et al.
Biomacromolecules, 12(1), 156-166 (2010-12-21)
Protein chemical degradations occur naturally into living cells as soon as proteins have been synthesized. Among these modifications, deamidation of asparagine or glutamine residues has been extensively studied, whereas the intermediate state, a succinimide derivative, was poorly investigated because of
Ohgi Takahashi et al.
Chemistry & biodiversity, 7(6), 1630-1633 (2010-06-22)
The rapid racemization of aspartic acid (Asp) residues in peptides and proteins is due mainly to the succinimide intermediate. However, there should be another mechanism for Asp racemization without intermediacy of the succinimide. The direct H-atom abstraction from the C(alpha)-atom
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