S8689
Fas Ligand, soluble human
recombinant, expressed in HEK 293 cells, lyophilized powder
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Synonym(s):
SuperFas Ligand™
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biological source
human
Quality Level
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-GE)
form
lyophilized powder
mol wt
32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
technique(s)
ligand binding assay: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FASLG(356)
Application
ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.
Biochem/physiol Actions
Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
Legal Information
SuperFas Ligand is a trademark of Alexis Biochemicals Corp.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.
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