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S8192

Sigma-Aldrich

Anti-phospho-Synapsin I (pSer603) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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MDL number:
MFCD03792019
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, Xenopus, bovine, human, zebrafish, rat

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000 using rat brain hipoccampal tissue homogenate

UniProt accession no.

P17600

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer603)

Gene Information

human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)

Immunogen

synthetic phosphorylated peptide derived from the region of rat synapsin I that is phosphorylated on serine 603.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in 10 mM HEPES buffer, pH 7.5, and 150 mM NaCl containing 100 μg/ml bovine serum albumin and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhenxia Qin et al.
PloS one, 8(11), e80758-e80758 (2013-11-14)
Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT). Mice deficient in PIMT accumulate isoAsp-containing proteins, resulting in cognitive deficits, abnormal neuronal physiology and cytoarchitecture
Jing Zhang et al.
Journal of neuroendocrinology, 25(8), 753-761 (2013-05-18)
Hypothalamic glutamate (Glu) and γ-GABA neurotransmission are involved in the ovarian hormone-induced gonadotrophin-releasing hormone (GnRH)/luteinising hormone (LH) surge in rodents. Studies have shown that reduced Glu and increased γ-GABA in the rostral preoptic area (rPOA) of the hypothalamus, where most
Heather D VanGuilder et al.
The European journal of neuroscience, 28(1), 1-11 (2008-07-30)
Diabetic retinopathy can result in vision loss and involves progressive neurovascular degeneration of the retina. This study tested the hypothesis that diabetes decreases the retinal expression of presynaptic proteins involved in synaptic function. The protein and mRNA contents for synapsin
Dillon Y Chen et al.
Nature neuroscience, 15(12), 1707-1714 (2012-11-20)
Emotionally important events are well remembered. Although memories of emotional experiences are known to be mediated and modulated by stress hormones such as glucocorticoids, little is known about the underlying molecular mechanisms. We found that the hippocampal glucocorticoid receptors that

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