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S7389

Sigma-Aldrich

SB-269970 hydrochloride

powder, ≥98% (HPLC)

Synonym(s):

(R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride, SB 269970A

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O3S · HCl
CAS Number:
261901-57-9
Molecular Weight:
388.95
MDL number:
MFCD03788020
UNSPSC Code:
12352200
PubChem Substance ID:
24278708
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 75 to 90°, c = 1.0 in DMSO

storage condition

desiccated

solubility

H2O: 10 mg/mL, clear (warmed to 60 °C)

storage temp.

2-8°C

SMILES string

Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3

InChI

1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1

InChI key

XQCJOYZLWFNDIO-PKLMIRHRSA-N

Gene Information

human ... HTR7(3363)

Application

SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.
SB-269970 was used to study the role of 5-HT7 receptors in serotonin-induced hypothermia in rodents.6

Biochem/physiol Actions

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT7 receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.4 SB-269970 desensitizes and decreases the excitatory effects of 5-HT7 receptors in rat hippocampus.5
Selective 5-HT7 serotonin receptor antagonist.

Legal Information

Sold with the permission of GlaxoSmithKline Pharmaceuticals

comparable product

Product No.
Description
Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D R Thomas et al.
British journal of pharmacology, 130(2), 409-417 (2000-05-12)
Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. [(3)H]-SB-269970 (1 nM) showed full association with h5-HT(7(a))/293 membranes
Agnieszka Nikiforuk et al.
PloS one, 8(6), e66695-e66695 (2013-06-19)
A wide body of evidence suggests that 5-HT7 receptors are implicated in a variety of central nervous system functions, including control of learning and memory processes. According to recent preclinical data, the selective blockade of these receptors may be a
Krzysztof Tokarski et al.
Pharmacological reports : PR, 64(2), 256-265 (2012-06-05)
SB 269970, a 5-HT(7) receptor antagonist may produce a faster antidepressant-like effect in animal models, than do antidepressant drugs, e.g., imipramine. The present work was aimed at examining the effect of single and repeated (14 days) administration of SB 269970
Shun-Fan Wu et al.
Scientific reports, 5, 12247-12247 (2015-07-17)
Dopamine (DA) is a signal moiety bridging the nervous and immune systems. DA dysregulation is linked to serious human diseases, including addiction, schizophrenia, and Parkinson's disease. However, DA actions in the immune system remain incompletely understood. In this study, we
Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue
Klotz JL, et al.
Journal of Animal Science, 91(9), 4492-4500 (2013)
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