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Merck
CN

S7135

Span® 85

Synonym(s):

Sorbitane trioleate

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About This Item

CAS Number:
26266-58-0
NACRES:
NA.25
PubChem Substance ID:
24899734
UNSPSC Code:
12161900
EC Number:
247-569-3
MDL number:
MFCD00133820

Key Documents

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InChI key

ZBNRGEMZNWHCGA-WECPCUOASA-N

InChI

1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-52-54(61)59-60(68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)55(53-66-59)67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27+/t54-,55+,59-,60-/m1/s1

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C\CCCCCCCC

description

non-ionic

form

viscous liquid

mol wt

957.52 g/mol

mp

14 °C (at 1.013 hPa)

solubility

chloroform: 50 mg/mL, clear, faintly to light yellow

density

0.947 g/cm3 at 20 °C

HLB

1.8

application(s)

cleaning products

Quality Level

200

Related Categories

General description

Sorbitane trioleate, or Span 85, is a non-ionic detergent.

Application

Sorbitane trioleate, or Span 85, has been used in a study to develop a novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants. It has also been used in a study to analyze the application of liquid chromatography in polymer non-ionic antistatic additives.

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≥ 60%; linoleic acid (C18:2) 3 - 12%; linolenic acid (C18:2) ≤ 3%; palmitoleic acid (C16:1) 2 - 6%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

437.0 °F

flash_point_c

225 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000520864
0000520863
0000520863
0000520864
0000505444

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M Victoria González-Rodríguez et al.
Journal of separation science, 33(22), 3595-3603 (2010-10-12)
This article investigates the applicability of HPLC-UV, ultra performance LC-evaporative light-scattering detection (UPLC-ELSD), HPLC-ESI(+)-MS and HPLC-hybrid linear ion trap (LTQ) Orbitrap MS for the analysis of different non-ionic antistatic additives, Span 20, Span 60, Span 65, Span 80, Span 85
A novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants
Tan, Y., et al.
International Journal of Pharmaceutics, 413, 7-7 (2011)
[Plausibility of the therapy concept].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 61(10), 826-827 (2010-10-12)
Determination of sorbitan trioleate in metered-dose inhalers by supercritical-fluid chromatography.
M Di Maso et al.
Journal of pharmaceutical and biomedical analysis, 8(3), 303-305 (1990-01-01)
Yang Liu et al.
Journal of colloid and interface science, 290(1), 259-266 (2005-06-07)
The nonionic surfactant of sorbitan trioleate (Span 85) was modified with Cibacron Blue F-3GA (CB) as an affinity surfactant (CB-Span 85) to form affinity-based reversed micelles in n-hexane. The reversed micelles formed by the mixture of Span 85 and CB-Span
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