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S7001

Sigma-Aldrich

Strychnine hemisulfate salt

≥98.0%, suitable for ligand binding assays and NMR

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Synonym(s):
Strychnidin-10-one sulfate (2:1)
Linear Formula:
C21H22N2O2 · 1/2H2SO4
CAS Number:
60-41-3
Molecular Weight:
383.45
EC Number:
200-477-7
MDL number:
MFCD00068328
UNSPSC Code:
12352210
PubChem Substance ID:
329824573
NACRES:
NA.26

Assay

≥98.0%

Quality Level

100

form

powder

technique(s)

NMR: suitable
ligand binding assay: suitable

color

white to off-white

SMILES string

OS(O)(=O)=O.O=C1C[C@@H]2OCC=C3CN4CC[C@@]56[C@@H]4C[C@@H]3[C@@H]2[C@@H]5N1c7ccccc67.O=C8C[C@@H]9OCC=C%10CN%11CC[C@@]%12%13[C@@H]%11C[C@@H]%10[C@@H]9[C@@H]%12N8c%14ccccc%13%14

InChI

1S/2C21H22N2O2.H2O4S/c2*24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;1-5(2,3)4/h2*1-5,13,16-17,19-20H,6-11H2;(H2,1,2,3,4)/t2*13-,16-,17-,19-,20-,21+;/m00./s1

InChI key

GOOCRIHPADOQAS-ZNUXJMJHSA-N

Related Categories

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300 + H330,H410

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Mari Hondo et al.
PloS one, 6(9), e25076-e25076 (2011-09-29)
Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood. We confirmed the effects
Adam C Roberts et al.
PloS one, 14(4), e0214374-e0214374 (2019-04-05)
Zebrafish larvae have several biological features that make them useful for cellular investigations of the mechanisms underlying learning and memory. Of particular interest in this regard is a rapid escape, or startle, reflex possessed by zebrafish larvae; this reflex, the
Rong-Qing Chen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(9), 1948-1958 (2011-05-20)
Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct binding sites. Previous studies have reported that glycine induces long-term potentiation (LTP) through the activation of synaptic NMDARs.
Louise Adermark et al.
Frontiers in systems neuroscience, 5, 85-85 (2011-10-27)
The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the
PeiPei Chau et al.
Addiction biology, 16(4), 591-599 (2011-07-28)
Studies have indicated that the metabotropic glutamate receptor 5 (mGluR5) antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) decreases ethanol self-administration, and the same receptor type was also suggested to be involved in the mechanism of action of the anti-craving substance acamprosate. Our previous research

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