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S4019

Sigma-Aldrich

Sodium bicarbonate

Hybri-Max™, powder, suitable for hybridoma, ≥99.5%

Synonym(s):

Sodium hydrogen carbonate

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10 MG
CN¥1,541.00

CN¥1,541.00

Estimated to ship onMay 16, 2025Details

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10 MG
CN¥1,541.00

About This Item

Linear Formula:
NaHCO3
CAS Number:
144-55-8
Molecular Weight:
84.01
Beilstein:
4153970
EC Number:
205-633-8
MDL number:
MFCD00003528
UNSPSC Code:
12161702
PubChem Substance ID:
57654616
NACRES:
NA.75

CN¥1,541.00

Estimated to ship onMay 16, 2025Details

Request a Bulk Order

grade

Hybri-Max™

Assay

≥99.5%

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

pH

8.3 (0.1 molfreshly prepared)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

solubility

water: soluble 100 mg/mL

density

2.16 g/mL at 25 °C (lit.)

SMILES string

[Na+].OC([O-])=O

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form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Application

Sodium bicarbonate has been used as a supplement:
  • in minimum essential medium (MEM)/flushing medium for embryo isolation[1]
  • in TCM 199 medium for the collection of cumulus-oocyte complexes (COCs) and in vitro maturation (IVM)[2]
  • in IVM medium for in vitro maturation of COCs[3]

Biochem/physiol Actions

Sodium bicarbonate occurs naturally as the mineral nahcolite. It is used to prepare many sodium salts as well as a carbon dioxide source. Sodium bicarbonate is used in the manufacture of fire extinguishers and cleaning agents. Bicarbonate plays an important role in pH regulation in vivo. In biochemistry, molecular biology, and chromatography, sodium bicarbonate is used as a buffer. This Hybri-Max™ product is suitable for use in hybridoma and cell culture research (2.2 mg/ml).

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCF4307
    SLBZ4817
    SLBZ3755
    SLBV1806
    SLBT2734

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    The effect of estrous ewe serum and heparin on in vitro fertilization and subsequent embryonic development in sheep
    Li F, et al.
    Small Ruminant Research, 63(3), 226-232 (2006)
    The effects of L-ergothioneine and L-ascorbic acid on the in vitro maturation (IVM) and embryonic development (IVC) of sheep oocytes
    Development, 1, 5-14 (2010)
    Shay P McGuinness et al.
    Critical care medicine, 41(7), 1599-1607 (2013-05-21)
    Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute
    Sophia Zoungas et al.
    Annals of internal medicine, 151(9), 631-638 (2009-11-04)
    Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
    Eric A J Hoste et al.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
    There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
    View All Related Papers

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