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S3699

Sigma-Aldrich

Anti-SEL1L (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-SEL1-like, Anti-Sel-1 suppressor of lin-12-like (C. elegans), Anti-Suppressor of lin-12-like
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~100 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-5 μg using lysate of human MCF-7 cells
indirect immunofluorescence: 2-4 μg/mL
western blot: 0.5-1.0 μg/mL using whole extracts of human MCF-7 cells

UniProt accession no.

Q9UBV2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SEL1L(6400)

General description

SEL1L (Sel-1-like) is a type I transmembrane glycoprotein, that is located in ER (endoplasmic reticulum). It is considered as a putative tumor suppressor gene. It is located on chromosome 14q.
SEL1L is highly expressed in the pancreas.

Application

Anti-SEL1L (N-terminal) antibody produced in rabbit has been used in
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

SEL1L (Sel-1-like) participates in the degradation pathway linked with endoplasmic reticulum (ER), malignant transformation and stem cells. It helps in the self regeneration of the neural stem cell. It controls cell fate developmental decision and homeostasis. It plays an important role in retaining homeostasis of endoplasmic reticulum throughout embryonic growth of vertebrate.
SEL1L is involved in cell growth and cancer progression.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians
Liu Q, et al.
Molecular Carcinogenesis, 51(5), 433-438 (2012)
SEL1L a multifaceted protein playing a role in tumor progression
Biunno I, et al.
Journal of Cellular Physiology, 208(1), 23-38 (2006)
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy
Mellai M, et al.
Oncotarget, 6(14), 12452-12467 (2015)
Rong Du et al.
BMC cancer, 21(1), 237-237 (2021-03-08)
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, is a RAS inhibitor that selectively dislodges active RAS proteins from cell membrane, inhibiting downstream signaling.
Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid
Cattaneo M, et al.
The Journal of Biological Chemistry, 289(5), 2826-2838 (2014)
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