S3134
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
lyophilized powder, ≥2,000 units/mg solid
Synonym(s):
Streptokinase from Streptococcus hemolyticus
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About This Item
form
lyophilized powder
Quality Level
specific activity
≥2,000 units/mg solid
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
InChI key
XRZWVSXEDRYQGC-UHFFFAOYSA-N
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General description
Research area: Cell signaling
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Application
Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Biochem/physiol Actions
Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.
Unit Definition
One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.
Physical form
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 287-307 (2004)
Streptokinase--a clinically useful thrombolytic agent
Banerjee A, et al.
Biotechnology Advances, 22(4), 2004-2004 (2004)
Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
D Collen et al.
Blood, 84(3), 680-686 (1994-08-01)
Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East
Al-Zakwani, I., et al.
Journal of the American Medical Association, 34(3), 445-451 (2012)
Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema
Bouros D, et al.
Thorax, 49(9), 852-855 (1994)
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