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S2947

Sigma-Aldrich

Anti-Synapsin II (C-terminal) antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-SYN2, Anti-SYNII, Anti-SYNIIa, Anti-SYNIIb, Anti-Synapsin 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~74 kDa (synapsin IIa)

species reactivity

human, mouse, rat

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.25-0/5 μg/mL using extracts of HEK-293T cells expressing human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate

UniProt accession no.

Q92777

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SYN2(6854)
mouse ... Syn2(20965)
rat ... Syn2(29179)

General description

Synapsins are a family of neuron-specific phosphoproteins that are localized on the cytoplasmic surface of small synaptic vesicles. Synapsins are ubiquitously expressed in neurons. The synapsin 2 (Syn2) gene is located on human chromosome 3p25. It belongs to the neuronal phosphoprotein family.

Specificity

Anti-Synapsin II(C-terminal) specifically recognizes human, rat and mousesynapsin II.

Immunogen

synthetic peptide corresponding to amino acids 569-586 of rat synapsin IIa isoform, conjugated to KLH. This sequence is identical in rat synapsin IIa, human synapsin IIa, and mouse synapsin II, and is not found in rat and human synapsin IIb.

Application

Anti-Synapsin II (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Synapsins regulate synaptic vesicle clustering and the formation of synaptic terminals. Synapsin II (Syn2) is involved in the formation of synaptic terminals during neuronal development. It can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. It is proposed as a candidate associated with increased vulnerability to schizophrenia. It plays an important role in synaptogenesis and neurotransmitter release. Syn2 also helps to locate nitric oxide synthase to the vicinity of its targets.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slightturbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

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Flash Point(C)

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Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Distinct roles of synapsin I and synapsin II during neuronal development
Ferreira A, et al.
Molecular Medicine, 4(1), 22-28 (1998)
Association of synapsin 2 with schizophrenia in families of Northern European ancestry
Saviouk V, et al.
Schizophrenia Research, 96(1-3), 100-111 (2007)
Essential functions of synapsins I and II in synaptic vesicle regulation
Rosahl TW, et al.
Nature, 375(6531), 488-493 (1995)
Role of presynaptic phosphoprotein synapsin II in schizophrenia
Molinaro L, et al.
World Psychiatry, 5(3), 260-260 (2015)
Diane T Stephenson et al.
Molecular autism, 2(1), 7-7 (2011-05-18)
The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus callosum. The goal of this study was to

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