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Merck
CN

S2501

Spermidine trihydrochloride

From microbial,synthetic, ≥98% (TLC), nNOS inhibitor, powder

Synonym(s):

N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

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About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH2 · 3HCl
CAS Number:
334-50-9
Molecular Weight:
254.63
NACRES:
NA.32
PubChem Substance ID:
24277993
UNSPSC Code:
12352204
EC Number:
206-379-0
MDL number:
MFCD00012918
Beilstein/REAXYS Number:
3552356

Key Documents

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Product Name

Spermidine trihydrochloride, ≥98% (TLC)

InChI key

LCNBIHVSOPXFMR-UHFFFAOYSA-N

InChI

1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H

SMILES string

Cl[H].Cl[H].Cl[H].NCCCCNCCCN

biological source

microbial
synthetic

assay

≥98% (TLC)

form

powder

mp

257-259 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

storage temp.

room temp

Quality Level

200

Gene Information

human ... NOS1(4842)

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Application

Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Disclaimer

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

General description

The nitric oxide synthase (nNOS) gene is localized on human chromosome 12q24.22. The enzyme is involved in the production of nitric oxide.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0836
BCCN9724
BCCP0072
BCCN3812
BCCM5076

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Physical interactions between DNA and sepiolite nanofibers, and potential application for DNA transfer into mammalian cells.
Castro-Smirnov FA
Scientific Reports, 6, 36341-36341 (2016)
Ayesha Kabir et al.
Biochimica et biophysica acta. General subjects, 1864(5), 129557-129557 (2020-02-12)
Polyamines can induce protein aggregation that can be related to the physiology of the cellular function. Polyamines have been implicated in protein aggregation which may lead to neuropathic and non neuropathic amyloidosis. Change in the level of polyamine concentration has
Neuronal Nitric Oxide Synthase (nNOS, NOS1) rs693534 and rs7977109 Variants and Risk for Migraine.
Garcia-Martin E
Headache, 55(9), 1209-1217 (2015)
Stefania D'Adamo et al.
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Methamphetamine (METH) is a widely abused psychostimulant, whose hyper-rewarding property is believed to underlie its addictive effect, but the molecular mechanism regulating this effect remains unclear. We previously reported that decreased expression of a novel microRNA (miRNA), novel-m009C, is implicated
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