S193
Anti-Synapsin I antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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Synonym(s):
Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen ~80 kDa (Synapsin Ia)
species reactivity
rat, mouse, human, bovine
technique(s)
dot blot: 1:1000
immunohistochemistry (frozen sections): 1:2000
immunoprecipitation (IP): 1 μg
indirect immunofluorescence: 1:2000
western blot: 1:1000
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)
General description
Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.
Immunogen
synapsin I from bovine brain.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.
- Western Blotting (1 paper)
- immunohistochemistry
- immunoblotting
- immunoprecipitation
- ELISA.
Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.
Biochem/physiol Actions
Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.
Physical form
Lyophilized from ammonium bicarbonate (5 mM)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
Cruceanu C, et al.
BMC Psychiatry, 16(1), 286-286 (2016)
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.
Huttner W B, et al.
The Journal of Cell Biology, 96(5), 1374-1388 (1983)
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
Paemka L, et al.
PLoS ONE, 8(12), e80737-e80737 (2013)
Andrew San Antonio et al.
The Journal of comparative neurology, 522(6), 1333-1354 (2013-10-30)
The hippocampal CA2 subfield was initially identified by Lorente de Nó as an anatomically distinct region based on its cytoarchitectural features. Although there is an enormous body of literature on other hippocampal subfields (CA1 and CA3), relatively little is known
Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I.
Giannandrea M, et al.
PLoS ONE, 8(6), e67724-e67724 (2013)
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