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S1450

Sigma-Aldrich

Anti-Superoxide Dismutase (MnSOD) (DD-17)−Cy3 antibody produced in rabbit

1-2 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Superoxide Dismutase 2, Anti-Manganese dependent SOD, Anti-Mitochondrial SOD, Anti-SOD2, Anti-Superoxide dismutase 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

200

conjugate

CY3 conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

packaging

antibody small pack of 25 μL

concentration

1-2 mg/mL

technique(s)

direct immunofluorescence: 2-5 μg/mL using human HeLa, rat NRK and mouse 3T3 cells.

UniProt accession no.

P04179

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SOD2(6648)

Related Categories

General description

The SOD2 (superoxide dismutase 2) gene is mapped to human chromosome 6q25.3. The encoded protein functions as a tetramer and is localized to mitochondria.

Immunogen

synthetic peptide corresponding to amino acid residues 183-199 of human superoxide dismutase (MnSOD), conjugated to KLH. The corresponding sequence is conserved in many eukaryotes.

Application

Anti-Superoxide Dismutase (MnSOD) (DD-17)-Cy3 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Superoxide dismutase 2 (SOD2) is an antioxidant enzyme and catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen. The enzyme offers protection against oxidative damage induced by reactive oxygen species and is also radioprotective. The gene is associated with the metastasis and invasion process of salivary adenoid cystic carcinoma. Manganese SOD is involved in detoxification.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Patrick D Bhola et al.
The Journal of clinical investigation, 126(10), 3827-3836 (2016-09-07)
Upfront resistance to chemotherapy and relapse following remission are critical problems in leukemia that are generally attributed to subpopulations of chemoresistant tumor cells. There are, however, limited means for prospectively identifying these subpopulations, which hinders an understanding of therapeutic resistance.
Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase.
Azadmanesh J, et al.
Journal of Structural Biology, 199(1), 68-75 (2017)
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma.
Chang B, et al.
Scientific Reports, 6, 25918-25918 (2016)
Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue.
Zhang Z, et al.
Oncotarget, 8(5), 7791-7791 (2017)
Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma.
Li S, et al.
Oncotarget, 7(22), 32408-32408 (2016)
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