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S1314

Sigma-Aldrich

Monoclonal Anti-SERCa2 ATPase antibody produced in mouse

clone 2A7-A1, ascites fluid

Synonym(s):

Anti-ATP2B, Anti-DAR, Anti-DD, Anti-SERCA2

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About This Item

MDL number:
MFCD00802883
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2A7-A1, monoclonal

mol wt

antigen 110 kDa

contains

0.05% sodium azide

species reactivity

guinea pig, human, canine, mouse, rat, rabbit

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

UniProt accession no.

P16615

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATP2A2(488)
mouse ... Atp2a2(11938)
rat ... Atp2a2(29693)

General description

SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.

Immunogen

canine cardiac sarcoplasmic reticulum vesicles

Application

Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.

Biochem/physiol Actions

Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca2+. ATP2A2 mutation may cause Darier disease (DD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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[Analysis of ATP2A2 gene mutations in a pedigree and a sporadic case with Darier disease]
Zhao X, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 33(5), 641-644 (2016)
Modulation of sarcoplasmic reticulum Ca(2+)-ATPase by chronic and acute exposure to peroxynitrite
Gutierrez-Martin Y, et al.
European Journal of Biochemistry, 271(13), 2647-2657 (2004)
Clinical case of acral hemorrhagic Darier's disease is not caused by mutations in exon 15 of the ATP2A2 gene
Pecina-Slaus N, et al.
Collegium Antropologicum, 27(1), 125-133 (2003)
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Revuelta-Lopez E, et al.
Journal of Molecular and Cellular Cardiology, 85, 25-36 (2015)
Maricela García-Castañeda et al.
The Journal of physiology, 595(13), 4167-4187 (2017-03-18)
Mutations in the gene encoding poly(A)-binding protein nuclear 1 (PABPN1) result in oculopharyngeal muscular dystrophy (OPMD). This disease is of late-onset, but the underlying mechanism is unclear. Ca2+ stimulates muscle growth and contraction and, because OPMD courses with muscle atrophy
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