S101
(R)-(+)-SKF-38393 hydrochloride
≥98% (HPLC), solid
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About This Item
Empirical Formula (Hill Notation):
C16H17NO2 · HCl
CAS Number:
Molecular Weight:
291.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
SMILES string
Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
InChI key
YEWHJCLOUYPAOH-PFEQFJNWSA-N
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D +16.1°, c = 1.2 in methanol(lit.)
storage condition
desiccated
color
off-white to light tan
solubility
0.1 M HCl: 1.2 mg/mL, ethanol: 3.4 mg/mL, H2O: 5 mg/mL, aqueous base: unstable
Quality Level
Related Categories
Application
(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Biochem/physiol Actions
(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a benzazepine derivative, exhibits anorectic effects.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Solutions may be stored for several days at 4 °C.
Disclaimer
Light sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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M R Zarrindast et al.
Pharmacology, 87(1-2), 85-89 (2011-01-19)
Both the dopamine receptor D(1) agonist SKF 38393 and the antagonist SCH 23390 are benzazepine derivatives that have been widely used as pharmacological tools and radioligands. Evidence suggests that behavioral effects of both compounds do not always correspond to their
A Bouron et al.
Neuroscience, 94(4), 1063-1070 (2000-01-07)
The present study was undertaken to better assess the role of dopamine on exocytosis. Since direct activation of adenylate cyclase (e.g., with forskolin) enhances neurotransmitter release it was of interest to see whether the activation of D1-type dopamine receptors, which
Carole Hyacinthe et al.
Neurobiology of disease, 63, 20-24 (2013-11-12)
Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
J L Katz et al.
Psychopharmacology, 107(2-3), 217-220 (1992-01-01)
The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N = 4) were trained with food reinforcement to press one of two levers after administration of
Zhi-Jun Zhang et al.
EMBO reports, 24(10), e56098-e56098 (2023-07-31)
A11 dopaminergic neurons regulate somatosensory transduction by projecting from the diencephalon to the spinal cord, but the function of this descending projection in itch remained elusive. Here, we report that dopaminergic projection neurons from the A11 nucleus to the spinal
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