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Merck
CN

S0677

Streptavidin from Streptomyces avidinii

recombinant, expressed in E. coli, lyophilized powder

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About This Item

CAS Number:
9013-20-1
UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:
MFCD00082035

Key Documents

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Product Name

Streptavidin from Streptomyces avidinii, recombinant, expressed in E. coli, lyophilized powder

recombinant

expressed in E. coli

form

lyophilized powder

capacity

4 mol/mol binding capacity (Biotin)

storage temp.

−20°C

Quality Level

200

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Application

Streptavidin from Streptomyces avidinii has been used-
  • for blocking of the AFM (atomic force microscopy) tip, during the measurement of unbinding forces in the avidin-biotin system
  • for coupling of anti-HA (hemagglutinin) antibodies during cell free synthesis and assembly of proteins on a biochip
  • for the coating of the gelatin flow phantoms to eventually determine the feasibility of IVUS (intravascular ultrasound) transducer for (biotinylated) microbubble-based drug delivery
  • to immobilize proteins and oligonucleotides

Biochem/physiol Actions

Streptavidin is an antibiotic that functions by binding to and depleting the essential vitamin biotin from the surrounding environment. Because of its unique properties, streptavidin has found various applications in biological studies, including immunotherapy, immunoassays, hybridization assays, lymphocyte activation, antigen localization and affinity chromatography.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Streptavidin is a biotin-binding protein that is obtained from Streptomyces avidinii. It is resistant to extreme temperature, pH, detergents and proteolytic enzymes. Streptavidin has a molecular weight of 60kDa and exists as a homotetramer.

Other Notes

One unit will bind 1.0 μg biotin.

Physical form

Lyophilized from 5 mM potassium phosphate buffer

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000491226
0000491223
0000491224
0000491223
0000491224

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Eduard Urich et al.
Scientific reports, 5, 14104-14104 (2015-09-29)
The blood-brain barrier and the blood-cerebrospinal fluid barrier prevent access of biotherapeutics to their targets in the central nervous system and therefore prohibit the effective treatment of neurological disorders. In an attempt to discover novel brain transport vectors in vivo
Moitrayee Bhattacharyya et al.
eLife, 9 (2020-03-10)
The many variants of human Ca2+/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme. CaMKII activity depends on the balance between activating and inhibitory
Cell-free protein synthesis and assembly on a biochip.
Heyman Y et al
Nature Nanotechnology, 7(6), 374-378 (2012)
Polymer Nanoparticles
Progress in Molecular Biology and Translational Science, 104 (2011)
The properties of streptavidin, a biotin-binding protein produced by Streptomycetes
Louis C
Archives of Biochemistry and Biophysics, 106 (1964)
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