S0198
Monoclonal Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in rat
clone 171001, purified immunoglobulin, lyophilized powder
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Synonym(s):
Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
UNSPSC Code:
51111800
NACRES:
NA.41
biological source
rat
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
171001, monoclonal
form
lyophilized powder
species reactivity
mouse, human
technique(s)
western blot: 1-2 μg/mL
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SHH(6469)
mouse ... Shh(20423)
Immunogen
purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog N-terminal peptide (aa 25-198).
Biochem/physiol Actions
Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles such as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during the development of brain and nervous system.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
related product
Product No.
Description
Pricing
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Alessia Omenetti et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(3), G595-G598 (2008-01-26)
Hedgehog (Hh) signaling modulates tissue remodeling by controlling the fate of Hh-responsive cells. Healthy adult livers exhibit little Hh activity. However, cells involved in adult liver repair, including myofibroblasts and progenitors, are capable of producing and responding to Hh ligands.
Fergal C Kelleher
Carcinogenesis, 32(4), 445-451 (2010-12-28)
To conduct a systematic review of the role that the hedgehog signaling pathway has in pancreatic cancer tumorigenesis. PubMed search (2000-2010) and literature based references. Firstly, in 2009 a genetic analysis of pancreatic cancers found that a core set of
Shohreh F Farzan et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(4), G844-G849 (2008-02-02)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given
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